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To elucidate the molecular mechanisms underlying MG-induced ferroptosis and kidney injury, we performed an intersection analysis of these differentially expressed genes with known ferroptosis-related gene sets, thereby identifying targeted genes that may be associated with ferroptosis-related mechanisms

Although direct measurement of H 2 O 2 is challenging, oxidative stress can be assessed using indirect biomarkers

This review provides an overview of the current knowledge of these new preservation strategies by machine perfusions and pharmacological interventions at different timing possibilities: in the organ donor, ex-vivo during perfusion machine reconditioning or after implementation in the recipient

Furthermore, ferroptosis-associated genes RBMS1, NOX4, FABP4, CYB5R1, CPEB1, and ATM, exhibit significant associations with immune cell infiltration and adverse clinical outcomes [172]

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

It is thought that 2-HG may serve as an oncometabolite by impairing cellular functioning via a variety of epigenetic and metabolic mechanisms ( 2-HG is known to interfere with glutaminergic signaling and the functioning of -KG dependent enzymes, including those that are central to the regulation of hypoxia-inducible factor 1-alpha (HIF1) and vascular endothelial growth factor (VEGF) (34)