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High doses may put additional strain on the kidneys, potentially causing adverse effects

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If you're in a risk group reduced food intake on GLP-1s, plant-based diet, long-term metformin or PPI use, over 50 and fatigue is dragging you down, checking your B12 is one of the highest-ROI moves you can make

Some research framings use a 5-days-on / 2-off pattern to build in a weekly break

Very high doses (such as those used for cyanide poisoning) should be used with caution and only if the potential benefit outweighs the risk

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