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Electronic supplementary material (PDF 584 kb) ESM 2 (download XLSX (XLSX 697 kb) Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

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Journal of Cosmetic Dermatology (2019)

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Furthermore, CETP activity was significantly higher in type 2 diabetic patients than in type 1 diabetic patients [14]

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Present at birth or clinically apparent in early childhood May be large (giant nevi) Silhouette Symmetric Sharp peripheral borders Junctional component Similar to common nevi but may be broader Possible associated papillomatous epidermal hyperplasia Possible pagetoid melanocytes Stromal component Evidence of maturation Frequently involves reticular dermis, may extend into subcutis Patterns of dermal involvement: diffuse, interstitial, or perivascular Adnexal involvement is common Nerve involvement may be seen Schwannian differentiation may be prominent Cellular or proliferative nodules may be present Heterologous elements may be present in large nevi Cellular or proliferative nodules may develop in congenital nevi, especially giant congenital nevi

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Downtime is minimal

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It is some interplay between trauma and genetic susceptibility that leads to the development of the disease

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