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However, this mutant still shows proteolytic processing in the recombinant protein as well upon transient expression in eukaryotic cells, suggesting processing does not use these residues for catalysis (Supplementary Figs

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The Combination of Quizartinib with Azacitidine or Low Dose Cytarabine Is Highly Active in Patients (Pts) with FLT3-ITD Mutated Myeloid Leukemias: Interim Report of a Phase I/II Trial, oral presentation

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Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of- function mutations of the met receptor in epithelial cells

Shameer K, Johnson KW, Glicksberg BS, Dudley JT, Sengupta PP