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Increased oxidative stress in autism may be due to (a) increased production of oxidative markers or (b) increased exposure to environmental pro-oxidants, or (c) deficiencies of antioxidants (ceruloplasmin, transferrin, SOD, GPx, catalase, reduced glutathione), impaired energy metabolism (NAD + , NADH, ATP, pyruvate, and lactate), and abnormal tryptophan catabolism

These mild, biocompatible reaction conditions allow crude products to be tested directly in living cells, thus marrying high-throughput chemistry (HTC) with miniaturized cell-based screens 26,29,30

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J Biol Chem 255:95309533 Griffith OW, Meister A (1979) Glutathione: interorgan translocation, turnover, and metabolism

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