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Both patients and physicians made a global evaluation at week 4 to evaluate the improvement achieved at the end of therapy as significant, moderate, mild or as absent

Emerging therapies such as mitochondrial biogenesis and gene replacement also hold promise for future treatment strategies

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450 However, in the phase 3 IMpassion131, the combination of atezolizumab with paclitaxel did not improve PFS or OS versus paclitaxel alone in patients with locally advanced TNBC, 451 making the role of atezolizumab in advanced disease controversial and needed to be further confirmed