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To activate the AIM2 inflammasome, THP-1 macrophages or peritoneal macrophages were primed with LPS (100 ng/mL) for 3 hr followed by (Poly(dA:dT), 2 g/mL) for 6 hr using LyoVec TM (InvivoGen, tlrl-patc) according to the manufacturers protocol

NAD Benefits: Mitochondrial Function, DNA Repair, Metabolism NAD+ drives ATP production through oxidative phosphorylation as the main electron donor in mitochondrial respiration

26 Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase, xanthine oxidase, nitric oxide synthase (NOS), lipoxygenase, and mitochondrial enzymes generate O 2

UK secondary reporting on the wider REDEFINE trial programme obesity arm cites up to 22.7% body-weight reduction at 68 weeks for CagriSema against roughly 1617% for semaglutide 2.4mg
