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, compromised blood brain barrier resulting in increased permeability, increased activation of microglia and astrocytes producing pro-inflammatory cytokines, and damaged myelin/white matter tracks [9], [24][36])

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The pro-inflammatory milieu intensifies neuronal damage, compromises bloodbrain barrier integrity, and exacerbates reperfusion-induced damage
Supplementary Video 7 Visualization of structural heterogeneity of 3 flanking region binding to ZSWIM8 MID as derived by 3D variability analysis

Nature 377 , 649 (1995)
