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Preclinically, these inhibitors reduce infarct volumes and improve functional recovery, not merely by lowering lactate but by reprogramming cellular metabolism: forcing neurons to resurrect oxidative phosphorylation in salvageable penumbral regions and redirecting glucose toward the PPP to bolster NADPH-dependent antioxidant defenses [208, 209]

PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

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Update on Antiepileptic Drugs 2019

Samantha M Olson, Margaret M Newhams, Natasha B Halasa, Ashley M Price, Julie A Boom, Leila C Sahni, Katherine Irby, Tracie C Walker, Stephanie P Schwartz, Pia S Pannaraj, Aline B Maddux, Tamara T Bradford, Ryan A Nofziger, Benjamin J Boutselis, Melissa L Cullimore, Elizabeth H Mack, Jennifer E Schuster, Shira J Gertz, Natalie Z Cvijanovich, Michele Kong, Melissa A Cameron, Mary A Staat, Emily R Levy, Brandon M Chatani, Kathleen Chiotos, Laura D Zambrano, Angela P Campbell, Manish M Patel, Adrienne G Randolph, Overcoming COVID-19 Investigators

(a) Proportion of genes marked by a peak of H3K27ac, Kpr, or both modifications at the promoter, for unaffected and differentially expressed genes in amPA mice