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Another proposed mechanism involves the binding of homocysteine to the collagenous matrix of bone, which may modify collagen properties and reduce bone strength (reviewed in 113)

Abbreviations DPPOS: Diabetes Prevention Program Outcomes Study GWAS: Genome-wide association study IF: Intrinsic factor MHRA: Medicines and Healthcare products Regulatory Agency PPI: Proton pump inhibitor QC: Quality control UKB: UK Biobank References Kim J, Ahn CW, Fang S, Lee HS, Park JS (2019) Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes

The consultation process helps determine if you're a good candidate and what kind of results you can actually expect

Its important to note that having vitamin B12 levels too high doesnt usually cause symptoms on its own, but it can be a marker for other medical concerns that need attention

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