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doi Voogt JL, Lee Y, Yang S, Arbogast L (2001) Regulation of prolactin secretion during pregnancy and lactation

Drugs that are completely retained within the vascular compartment, on the other hand, would have a minimum possible volume of distribution equal to the blood component in which they are distributed, eg, 0.04 L/kg body weight or 2.8 L/70 kg ( Table 32 ) for a drug that is restricted to the plasma compartment

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The most common normal localized reactions include: Redness (erythema) at the site Swelling or a small raised bump Tenderness or slight pain Mild warmth Itching Small bruising These reactions are typically: Localized to a small area (12 inches in diameter) Mild to moderate in intensity Resolve within 2448 hours Not progressively worsening Many patients will experience some degree of redness or swelling during the first week or two of therapy as the immune system acclimates