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During this process, glutathione changes from its reduced form (GSH) to its oxidized state (GSSG)

This was particularly evident in the mitochondrial proteins responsible for detoxifying H 2 S, and this downregulation was associated with a higher disease severity (70)

It does, however, affect the conversion of MTHF to BH4 (tetrahydrobiopterin), an important cofactor in the production of neurotransmitters, and the synthesis of nitric oxide

doi: 10.2337/diacare.28.1.120 [DOI] [PubMed] [Google Scholar] 124

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