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The use of a rat model, although widely accepted for preliminary biomedical research, may not entirely replicate the complex pathophysiological processes of premature ovarian insufficiency in humans

The peroxynitrite radical, which damages cells, is created when too much NO combines with a superoxide anion to oxidise and nitrate macromolecules, including GSH, proteins, lipids, and DNA

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Lv QQ, You C, Zou XB, Deng HZ

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[Google Scholar] 8.Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, et al

Our team occasionally recommended carnitine for people on valproic acid/Depakote, to help with residual side effects like muscle weakness and constipation