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Additionally, because the gene ontology analysis revealed an enrichment of calcium-regulated biological process in Lyso-high GBM cell lines, (Supplementary Fig

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Melatonin upregulates the pyruvate dehydrogenase complex (PDC), reprogramming pyruvate in mitochondria, promoting the metabolism of pyruvate to acetyl-CoA in mitochondria, and inhibiting the Warburg effect (Reiter et al., 2020)

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