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Nevertheless, future research should focus on examining temporal relationships between HPA axis function and immune-inflammatory or nitrosative stress pathways through biomarkers like TNF-, IL-10, TGF-, inducible NO synthase, NO production, protein nitrosylation, and bacterial translocation in ME/CFS patients to better understand their roles [79]

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doi: 10.1101/2024.07.25.605098 31 LiS.HuangY

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As BDNF drops, so does the capacity for LTP, leading to gradual but measurable deterioration in the ability to form and retrieve memories