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Since few years, targeted therapies emerged as a promising senolytic approach, and several molecules are under clinical evaluation

While receptor-mediated transcytosis (RMT) is the leading approach for transporting biologics into the brain, several complementary strategies aim to bypass or transiently modulate the blood-brain barrier (BBB)

Previous research has found that the actin-binding domain of thymosin 4 duplicated in a seven amino acid residues synthetic peptide with sequence of LKKTETQ was able to promote dermal and corneal repair in normal rats

For cell models in need of external metabolizing systems such as S9-mix, NAs are already activated extracellularly and the activated/reactive metabolites must cross both cell and nuclear membranes for DNA adduct formation

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Johansson ME, Jakobsson HE, Holmn-Larsson J, Schtte A, Ermund A, Rodrguez-Pieiro AM, et al

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