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SIRT1 also indirectly modulates key molecules in the insulin signaling pathway, such as insulin receptor substrate 2 (IRS2) by influencing members of the forkhead transcription factors (FOXO) family, ultimately alleviating insulin resistance [108,109,110]

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Furthermore, tubuloids obtained via urine from cystic fibrosis patients were used to assess treatment efficacy and circumvented the use of an invasive method to obtain patient material (Schutgens et al