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When present in over abundant levels reducing sugars like glucose or fructose react non-enzymatically with free amino groups of proteins, lipids, or nucleic acids to initially form Schiff bases or Amadori adducts ( Figure 2 ) ( Figure 2 Protein kinase C pathway Diabetes induced elevation in circulating glucose levels leads to the accumulation of glucose in cells independent of insulin for glucose transport

Other antimicrobials associated with acute kidney injury include aminoglycosides, rifampin (Rifadin), penicillin, cephalosporins, amphotericin B, and fluoroquinolones (Bird 2013

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