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Nuclear factor E2-related factor 2 (Nrf2) can reduce the expression of TfR1, regulate iron metabolism, maintain the balance of intracellular iron homeostasis, and limit the production of reactive oxygen species (ROS), thereby reducing ferroptosis (Li S

Chaplen et al., High levels of MG occur when the concentrations of their precursors are elevated, such as in hyperglycemia, impaired glucose utilization and triosephosphate isomerase deficiency (Ahmed et al., As previously mentioned, MG is one of the most potent glycating agents present in cells making its accumulation highly deleterious