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Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question

Clinical trials are ongoing with small-molecule TNF--converting enzyme, p38 mitogen-activated protein kinase and phosphodiesterase inhibitors that specifically interrupt the synthesis and signalling pathways for TNF- and downstream pro-inflammatory molecules such as IL-1, IL-6, nitric oxide synthase and cyclooxygenase-2

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Ludwig M.Q., Cheng W., Gordian D., et al

Based on clinical data on Semax, the peptide is well tolerated when administered intranasally in doses between 600mcg/daily and 12000mcg/daily [23, 24, 25]

Thereby, BPC 157 is easily applicable and safe without adverse effects (i.e., in ulcerative colitis trials) while toxicology studies showed that a lethal dose (LD1) can be not achieved (for review, see [1,2,3,4,5,6,7,8,9,10])