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Therapeutic strategies targeting ROS Antioxidant strategies Radical-focused strategies Traditional antioxidant strategies were fundamentally rooted in a simplistic, one-size-fits-all scavenging strategy (Tables 1 and 2)

Iron deficiency and iron overload are considered important causes of chronic metabolic diseases (such as T2DM or obesity) [48]

2.9 Histological examination For histological studies, part of the heart tissu was formalin-fixed and paraffin-imbedded before heart slicing

In this work, we develop a -glutamyl transpeptidase (GGT)-activable nanoprobe that maintains a neutral surface charge (10 mV) in the blood circulation, aiming to utilize the efficient cross of BBB via AMT-based drug delivery while avoiding the toxic side effects of cationic nanodrugs

Clinically, this results in increased blood pressure and heart rate due to unopposed sympathetic stimulation

Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides