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Given that ERs dynamically shuttled between the membrane, cytoplasm, and nucleus to orchestrate both rapid nongenomic and longterm genomic signaling cascades using preclinical models [492], CAPinduced modulation of ER localization represents a plausible and specific mechanism to influence estrogensensitive nociceptive circuits (Figure 5)

2015;6(9):e111

Cardioprotective activity It is well known that cardiovascular disease is a complex and multifactorial disease

This strategy holds promise for ameliorating lipid peroxidation and modulating the immune microenvironment in COPD models while circumventing systemic side effects (179)

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