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AOD-9604 is sold as a research compound and is not FDA-approved for human use

This pathway allowed AOD-9604 to be marketed in the United States as a dietary supplement without the efficacy evidence required for a New Drug Application (NDA)

Deficiency can contribute to irritability, low mood, and increased stress

While these effects are beneficial in specific contexts such as treating growth hormone deficiency in children, muscle wasting conditions, or severe catabolism, they create unwanted consequences when the goal is simply fat reduction

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Appetite Effects The question about appetite is interesting because the proposed mechanism could reasonably go either direction: Reduced lipogenesis and improved metabolic flexibility could produce secondary effects on appetite regulation NAD+ restoration has complex effects on hypothalamic appetite signaling Preclinical data do not consistently describe dramatic appetite changes In human use were it to become clinically available patient-reported appetite effects would be a relevant monitoring parameter, but the data do not currently support a strong a priori expectation