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A healthy gut microbiome (balanced community of microorganisms, including bacteria, viruses, and fungi) is believed to be essential for normal physiological activities, including the circadian rhythm and sleep (Figure 7) [168]

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Unless we stem this rising tide, the ensuing socio-economic impact is poised to exceed the management capacity of many healthcare systems

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Cardiac dysfunctions were significantly alleviated in ASC- or caspase-1-deficient mice, or following silencing of either NLRP3 or P2X7, a pyroptosis stimulating ATP receptor [88, 129, 130]
