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Status of clinical trials involving anti-IGFs and IGF-1R mAbs The preclinical findings that support IGF-1 and its receptor IGF-1R as potential therapeutic targets led to the initiation of many clinical trials in the last decade (Table 1)

Genetic polymorphisms of CBS may contribute to conditions such as hyperhomocysteinemia and have implications for cardiovascular diseases and metabolic disorders

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Vitamin C and Choline work together to combat oxidative stress and support cellular health

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Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies