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It also prevents early inactivation, degradation, and dilution in the circulation [133,134]

For type 2 diabetes management, the medication may be needed long-term as diabetes is a chronic condition requiring ongoing treatment, though some patients may be able to reduce or discontinue medication if significant weight loss and lifestyle modifications lead to remission of their diabetes

Damage Due to OxS (Oxidant Damage) Oxidant damage was measured as plasma concentrations of F2-isoprostanes (F2-I)

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To maintain their thiol redox homeostasis, they contain millimolar concentrations of the dithiolic polyamine-conjugate N 1 , N 8 -bis(glutathionyl)spermidine, known as trypanothione [T(SH) 2 ] (Fig

Blood 104, 409414 (2004)