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Astrocytes express elements of the class II endocytic pathway and process central nervous system autoantigen for presentation to encephalitogenic T cells

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Their substrates include HMG-CoA reductase inhibitors, anticancer agents, benzodiazepines, immunosuppressants, macrolide antibiotics, anesthetics, and antifungals such as terbinafine (Shang et al., 2024)

In different species, TRP superfamily is divided into 30 channels within seven subfamilies such as TRPA (ankyrin), TRPC (canonical), TRPM (melastatin), TRPML (mucolipin), TRPP (polycystin), TRPV (vanilloid), and TPRN (NomPC), nevertheless there are 28 subfamilies within 6 subgroups in mammalian (Hardie, 2011