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For example, alginate possesses a large number of carboxyl groups in its polymer framework, which are converted into negatively charged carboxylate ions in alkaline conditions, leading to pH-responsive expansion that accelerates drug release [345]

A high normal calculated GH secretion rate and amplified number of GH secretory bursts have been reported in pre-pubertal children with end-stage renal disease, likely due to attenuated IGF-1 feedback [8]

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