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Overall, the underlying pathophysiological mechanism of bone fragility in diabetes is very complex, including hyperglycemia, oxidative stress, and the accumulation of advanced glycosylation end products, which will damage the characteristics of collagen, increase bone marrow obesity, release inflammatory factors and adipokines from visceral fat, and may change the function of bone cells

Glutathione is often referred to as the "master antioxidant." Unlike glutamine, which is a single amino acid, glutathione is a tri-peptide

Causes and consequences of microRNA dysregulation in cancer

This reduces tumor initiation ability while simultaneously increasing the expression of solute carrier family 7 member 11 (SLC7A11), which protects tumor cells from lipid peroxidation and ferroptosis that promote tumor metastasis

Its applications span several critical areas of research, including protein-protein interaction studies, signal transduction pathways, and drug target identification

doi: 10.1007/s00702-014-1187-1 118 LoprestiALHoodSDDrummondPD
