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In its advanced stages, the bones begin to rub against one another, causing pain, stiffness and reduced mobility

PGC1alpha and mitochondrial metabolismemerging concepts and relevance in ageing and neurodegenerative disorders

doi: 10.1038/s41419-021-03452-x 27 LiSZhengLZhangJLiuXWuZ

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Immunofluorescence studies in brain sections further corroborates a shift from peripheral, honeycomb like staining in WT to a more diffuse cytosolic distribution in hyh embryos

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