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Early-phase clinical trials including a Phase 2 dose-ranging study published in the New England Journal of Medicine (2023) have demonstrated significant potential for weight reduction and metabolic improvement, generating considerable scientific interest

The potential for gastrointestinal adverse effects, particularly nausea and vomiting, may lead to dehydration and worsening of renal function in vulnerable patients

The trade-off is durability: because the peptide is recalibrating native processes rather than forcing a pharmacological state, results generally hold with less risk of immediate reversal upon discontinuation

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Despite the benzyl alcohol preservative, improper handling can introduce bacteria or other microorganisms that may overwhelm the preservative's protective capacity