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Statements Author contributions XF, NL and XL made data analysis

Furthermore, both cell development and the maintenance of different functions require the engagement of GPX4, as its genetic knockout or inactive form of expression leads to embryonic death lethality and subfertility in male mice ( Lipid peroxidation Fatty acids serve as vital cellular nutrients and also maintain a wide range of cellular functions, including the formation of cellular membranes and the transmission of cellular signals (Xie et al., 2020)

102 It should be noted that DNA damage accumulated during ageing, potentially contributing to the increase in chronic inflammation with age

Before absorption in the lumen, ascorbic acid can increase the solubility of minerals, as occurs with iron, and it can also form complexes with minerals, resulting in a chelate that is also taken up in the enterocyte (Subroto et al., 2021)

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