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Biopsy should attempt to obtain clear margins (1 to 3 mm) The histology of a partial biopsy may not be representative of the entire lesion when there is residual clinical pigmentation

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Lp(a) also interferes with other aspects of the normal processes of coagulation in addition to its effects on plasminogen function

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231 , 232 Most authorities wait at least several months before initiating therapy so that the adverse effects of the antiretroviral therapy are not confused with those caused by peginterferon or ribavirin