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It has a half-life of approximately six days, which supports once-weekly subcutaneous injection

A systematic review of dietary energy intake across the menstrual cycle reports that, in studies with rigorous phase verification (hormone assays or urinary LH), daily energy intake is typically higher in the luteal phase than in the follicular phase, with mean differences ranging from approximately 159 to 529 kcal/day [84]

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The mechanism is likely related to reduced caloric intake and metabolic adjustment rather than a direct drug effect

But a surprising number of them are quietly leaving results on the table because of one overlooked variable: protein intake that sounds high but functionally isn't

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