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Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells

Methylcobalamin is the active, methylated form

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In the Krebs cycle, adenosylcobalamin can induce the accumulation of succinate, an antagonist of histone and DNA demethylation reactions catalyzed by enzymes of the 2-oxoglutarate-dependent dioxygenase family, which may favor the activation or inhibition of gene expression ( Figure 5 )