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Similar to a Phe-reduced diet, if co-administered with neurotransmitter precursors, a sapropterin dihydrochloride treatment consistently improved almost all clinical symptoms in PTPSD, DHPRD (see comment below), and AR-GTPCHD, including movement disorders (dystonia, oculogyric crises, choreoathetosis, tremor, hypotonia, hypertonia, rigidity), epileptic seizures, sleep problems, gastrointestinal disturbances (hypersalivation, swallowing difficulties), anthropometric parameters, developmental delay, and behavioural abnormalities

It is naturally present in human blood, saliva, urine, and its plasma concentration declines with age from approximately 200 ng/mL at age 20 to under 80 ng/mL after age 60

Expression of Glycosaminoglycans and Small Proteoglycans in Wounds: Modulation by the Tripeptide Copper Complex Glycyl-L-Histidyl-L-Lysine-Cu2+ J

Mu L, Tang J, Liu H, et al

The ViaNase TM is an electronic atomizer device used to target a nasal spray to the respiratory epithelia of the nasal cavity and the olfactory region [8,10]