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Once deposited and exposed to lung fluids, inhaled aerosols dissolve and subsequently release their embedded nanoparticles [33]

Treatment with B 12 injections is efficacious in restoring normal metabolism, alleviating symptoms, and reversing haematological and some neurological complications of deficiency.23 Anaemia usually resolves within six to eight weeks, but coexisting iron deficiency may be present and need oral iron supplementation7 and, in severe cases, parenteral iron infusion

After AIS, neuroinflammation and oxidative stress interweave with each other, jointly act and continuously activate the SNS, thereby leading to a sharp increase in catecholamine levels

For generation of VLP containing plasmid of interest (scramble, GFP or shRNA), the day before transfection, cells were seeded on 10 cm culture plates to reach 70% confluence for transfection

Rare cases of severe anaphylactic reactions have been reported with IV use