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Water-loving small molecules cannot traverse a lipid barrier and fat-loving molecules can get trapped within the barrier

doi: 10.1016/j

2025 Jan 6;9(2):bvae223

J Neurosci 22:78567861

Morphological and developmental alterations have been observed in the M1 of SMA murine models, including a selective degeneration of layer 5 pyramidal neurons and differences in intrinsic synaptic and neuronal properties, from pre-symptomatic to late symptomatic disease stages [10, 18, 19]