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The combined four-component algorithm adjusts for age and folate status, in view of the likely increase in serum MAA with age in the elderly, and the increase in serum Hcy in folate deficiency

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The rate of increase depends on various factors, including the quantity and strength of the alcohol consumed, body weight, metabolism, and the rate of alcohol absorption into the bloodstream

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Cyanocobalamin is a cofactor for several enzymes which participate in crucial metabolic reactions, such as single carbon metabolism, cell growth and DNA synthesis