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Currently, there is significant interest in the mechanistic and clinical roles of cuproptosis and ferroptosis in the pathogenesis of Wilson disease, particularly in relation to genetic alterations involving the ATPB7 gene

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Importantly, NADPH is required as a coenzyme for many xenobiotic metabolism and antioxidant enzymes, including AKR, NAD(P)H: quinone oxidoreductase1 (NQO1), and GSR1

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