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Alpha-1 Antitrypsin Deficiency and Oxidative Stress Among individuals with COPD, those with alpha-1 antitrypsin deficiency have a distinct pattern of oxidative stress characterized by an increase in exhaled breath nitric oxide, accelerated polymerization of oxidized Z-AT (Glu342Lys) protein which increases inflammation, and decreased serum glutathione and catalase before the appearance of COPD

10.1038/s41578-021-00358-0 62 HussainM

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Alterations in cytokine/chemokine expression during organ-to-organ communication established via acetaminophen-induced toxicity

Individual cages (interior dimensions of 31.5 15.5 (floor), up to 34.5 19.0 (ceiling) 13.0 cm tall) included a ceiling-mounted, hut into which mice can climb, for automated body mass measurements, a food hopper (3 mg resolution), and water spigot

While leukotrienes are secreted from senescent cells, they appear to function in parallel to SASP factors (Hamsanathan and Gurkar, 2022)
