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The authors of the study proposed that the lack of effects observed was due to the unexpectedly high anti-fatigue activity of the placebo used [18]

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Management strategies employed in a few cases of TMAU include dietary modifications, pharmacotherapy, communication strategies, and specific treatments such as MiraDry, as shown in [Table/Fig-6] [32-34]

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More recent systematic reviews and meta-analyses published between 2020 and 2022 have broadly confirmed this picture, reporting small, short-term reductions in body weight and body mass index, particularly in older adults and individuals with obesity or metabolic conditions, but with effect sizes that remain clinically modest