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Description
doi: 10.1016/S0140-6736(10)60888-4
While treatment of hepatocytes with phenolic antioxidants induce binding of Nrf2/JunD/Maf to human GCLCs ARE4 to trans -activate the gene, it appears that TGF-1 treatment in type II alveolar cells induced binding of Fra-1/c-Jun dimer to the internal AP-1 sequence of the ARE4 site and suppressed GCLC expression (Jardine et al., 2002)

Maintain the supporting factors that affect outcomes
AOD-9604 is not approved as a drug for obesity or any other condition by the U.S

doi:10.1007/s12178-025-09990-7
Matsui and Williams, 2010)
