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Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats

Am J Pathol 181: 14261435, 2012

A key enzyme in the anabolic utilization of ketone bodies is cytosolic acetoacetyl-CoA synthetase, which catalyses the coupling of acetoacetate to CoA in a reaction dependent on ATP with acetoacetyl-CoA as the product

The water-based formulation penetrates rapidly to the epidermis via osmosis

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