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Patients with BSEP deficiency and tyrosinemia are of greater risk of developing hepatocellular carcinoma (HCC)

We demonstrate the establishment of this workflow and how it is exploited to rapidly identify druggable targets and human approved compounds with antiviral efficacy in vitro and in vivo

During the cell immune response, vaccinia virus infection rapidly stabilized HIF-1, which was mediated by VACV protein C16 bound to the human oxygen-sensing enzyme PHD2 and inhibited its hydroxylation of HIF-1 under normoxia [151]

doi:10.1056/NEJMoa2021372 Dasgeb B, Kornreich D, McGuinn K, Okon L, Brownell I, Sackett DL

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