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Based on the data available in 2015, EFSA did not identify any known health risks associated with the use of dietary supplements, so no maximum dose or maximum daily intake, also known as a tolerable upper intake, was set (EFSA, 2015)

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"Anaemia and related nutrient deficiencies after Roux-en-Y gastric bypass surgery: a systematic review and meta-analysis"

However, a decline in NAD + levels can precipitate a NAD + /NADH redox imbalance, resulting in an accumulation of excess NADH