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Moreover, the NF-B signaling pathway has been implicated in immunosuppression and immune evasion in ovarian cancer cells partly via NFB-dependent production of IL-6, which impairs DCs but generates and recruits immunosuppressive MDSCs, and IL-8, which increases the expression of the immunosuppressive enzyme arginase [102]

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Numerous recent studies have demonstrated the critical role of oxidative stress, abnormal lipid metabolism, endoplasmic reticulum stress, various forms of cell death (including apoptosis, necroptosis, and ferroptosis), intestinal microbiota dysbiosis, liver immune response, cell autophagy, and epigenetic abnormalities in the pathogenesis of ALD