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Juglanin downregulates the expression of NOX4, decreases SOD activity, and inhibites the caspase-1 axis activation, and reduces IL-1 and IL-18 production, ameliorating cellular damage and exerting anti-inflammatory and anti-oxidant physiological utility (Sul and Ra, 2021)

Aura and other neurologic dysfunction in or with migraine

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In stark contrast, Retatrutide intervention induced 373 significant changes relative to the HFD group, with the vast majority (331 metabolites) being significantly down-regulated, and only 42 being up-regulated (Fig

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10.1038/srep19076 16 ChenZ.TianR.SheZ.CaiJ.LiH