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An immunohistochemical panel aimed at a risk stratification can encompass: - p16, which may disclose uneven immunoreactivity or clonal loss as an atypical feature ( - HMB45, which may be unevenly distributed, with loss of the gradient pattern seen in benign tumors ( - Cell cycle-related protein Ki67, which may show a high rate of expression and/or proliferative clusters in atypical lesions ( The traditional four-probe (targeting MYB , RREB , Cep6 , and CCND11 ) plus the anti- CDKN2A / Cep9 dual probe FISH examination may help refine the risk stratification of melanocytic tumors as recently proposed (86)

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