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Tirzepatide, the first dual GIP/GLP-1 receptor agonist (RA), received US Food and Drug Administration (FDA) approval for the treatment of T2DM in May 2022 and for chronic weight management in November 2023 [4]

During ferroptosis, autophagy facilitates the production of free iron by affecting the levels of iron input and output, storage, and transport [99, 100, 120]

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This suggests that metabolic rewiring via lipid pathways is a non-canonical mechanism by which the autophagy-ferroptosis balance is tilted toward tumor promotion

Genetic variation in SELENOS has been shown to influence the inflammatory response (Reference Curran, Jowett and Elliott65)

Thus, as a proper extension to the disturbed NO-system in hemostasis [39], the present work showed that L-NAME-induced thrombocytopenia and L-arginine-induced increased hemorrhage